|This issue is sponsored by:|
|1. Editor's Message
Carl Wonders, PhD
ISSCR 12th Annual Meeting, June 18-21, 2014, Vancouver, Canada. Several important deadlines are approaching this month:
Find out more about abstract submission, Travel and Poster Awards, registration and more in Section 2.
- Abstract Submission: the extended deadline is February 18 at 2 pm CST (USA). Don't miss this opportunity to submit an abstract to be considered for oral or poster presentations.
- Early Registration: The discount for early registration ends February 28. Register today to take advantage of the best rates and to be entered for a chance to win a seaplane tour for two.
ISSCR 2014 Elections. The 2014 elections for the ISSCR Board of Directors are now open! Current members are invited to:
- Vote for a vice president
- Vote for a new member of the ISSCR Board of Directors
- Endorse the re-appointment of six current directors
All eligible members should have received an email with ballot instructions. If you are not yet a member or have not renewed your membership for 2014, don’t miss your opportunity to participate. This is your opportunity to help shape the future direction of the ISSCR. Voting closes March 14. Find out more about the elections and meet the candidates. Contact Glori Rosenson (firstname.lastname@example.org; +1-224-592-5755) with questions.
ISSCR Connect. With two new member-exclusive seminar series, a new public webcast series and continued work on a new look, February is shaping up to be an exciting month on ISSCR Connect! See Section 3 for all the details.
4th International Conference on Stem Cell Engineering, March 16-19, 2014, Coronado, California, USA. Co-presented by the Society for Biological Engineering and the ISSCR. This meeting brings together biologists, engineers and clinicians who are working on cellular therapies to accelerate progress in designing the stem cell and its environment. Learn more about this meeting.
Global Controls in Stem Cells, November 5-7, 2014, Singapore. Expanding the global reach of our educational programming, the ISSCR is proud to partner with the Stem Cell Society Singapore to bring you Global Controls in Stem Cells as part of the ISSCR Regional Forum Series 2014. See our website for more information on this meeting.
Spotlight on ISSCR Member Sabine Middendorp. Get to know your fellow ISSCR members through our monthly Spotlight Series on the ISSCR website. We are over 4,100 members across 55+ countries; let’s make our world just a little bit smaller one member at a time. Click here to meet Dr. Sabine Middendorp.
Sponsor The Pulse and Get Noticed. Promote your products and services to more than 14,000 members of the stem cell community by being an exclusive sponsor of The Pulse. All issues for 2014 are fully committed. We will begin offering sponsorship for 2015 issues in June 2014. For information about sponsorship, contact Amy Claver.
|2. ISSCR 12th Annual Meeting
ISSCR 12th Annual Meeting
June 18-21, 2014
Vancouver, British Columbia, Canada
Co-sponsored by STEMCELL Technologies
|Abstract Submission Deadline
||EXTENDED to February 18
|Early Registration Deadline
Don’t Miss Out! The deadline to submit abstracts has been extended to February 18. If you haven’t yet submitted an abstract, you have another chance! Concurrent speaking slots are selected from the abstracts that we receive. This is your opportunity to present your latest research to the stem cell community. Read the call for abstracts for more information.
Be sure to apply for Travel and Poster Awards when submitting your abstract!
- Travel Awards include a complimentary meeting registration and a stipend to help defray the costs of traveling to Vancouver. To be considered for an award, you must complete the requested information when you submit your abstract.
- Poster Awards are given to outstanding poster presentations given by Trainee Members of the ISSCR. To be considered, you must indicate your eligibility when submitting your abstract.
The Early Registration Deadline is February 28. Register today for the best registration rates. Not yet a member? Apply for membership now and immediately take advantage of the reduced rates. Contact Nathan Chamberlain (email@example.com; +1-224-592-5756) with questions.
Plan your stay in Vancouver. The Headquarters Hotel for the ISSCR 12th Annual Meeting is the Pan Pacific Vancouver. Rooms are available at negotiated rates through the ISSCR Housing Service at this and other area hotels. Once you have completed your online meeting registration, you will automatically be taken to the housing reservation website. You can also follow the link in your registration email to access the housing service at a later date. See our hotel information page for more details.
Arrive early and participate in the Wednesday morning pre-meeting events. Each year we offer Focus Sessions and Industry Wednesday Symposia the Wednesday morning before the start of the Annual Meeting. These events provide additional opportunities for members, non-profit organizations and companies to extend the range of topics covered by the meeting.
Focus sessions – these member-organized presentations explore unique issues related to stem cell research. Currently two sessions are being organized; click the titles below to learn more about each session. If you are interested in proposing a Focus Session, download the application.
Industry Wednesday Symposia – these sessions give companies the opportunity to present topical scientific issues in stem cell science as framed by industry leaders. ThermoFisher has confirmed to present this year; if your company is interested in participating or would like more information, contact Amy Claver or Drew Rich.
Help us spread the word! Download the ISSCR 12th Annual Meeting PowerPoint® slide for use in your next presentation.
Visit our co-sponsor, STEMCELL Technologies.
|3. ISSCR Connect
ISSCR Connect is our online, educational and interactive portal that provides ongoing learning opportunities and the ability to make connections and open new avenues of communication in our fast moving field throughout the year.
Stem Cells in Focus Webcast (Public Channel)
Beginning February 20 at 2 pm ET (USA), the ISSCR will present a monthly webcast covering topical stories in stem cell research. Aimed at a public audience, this webcast will be presented by an expert in the field and will also include a moderated question and answer session with the audience.
This month, Deepak Srivastava, MD, will discuss the efforts of his and other labs to stimulate endogenous cardiac regeneration as a way of treating heart disease.
View a complete list of upcoming programs.
What's New in the ISSCR (Public Channel)
Broadcasting monthly, "What's New in the ISSCR" discusses the latest developments within the ISSCR. Hear about new programs, bring your questions and participate using the live chat and Q&A features! This month's program is on Thursday, February 13 beginning at 10 am ET (USA). Can't make it? The program will be available on-demand after the broadcast.
Building Organs with Stem Cells (Members Channel)
Stem Cells and Cancer (Members Channel)
|4. News Roundup
Edinburgh, UK. On February 4, a consortium of 26 public and private partners combined to establish the European Bank for Induced Pluripotent Stem Cells (EBiSC), the first such bank in Europe. Read the press release.
Washington D.C., USA. On February 4, the US District Court of Appeals for the DC Circuit upheld a lower court ruling that a stem cell treatment described as a procedure falls under the authority of the US Food and Drug Administration (FDA) as a product. This sets a precedent for regulatory oversight of certain stem cell treatments as drugs or biological products in the USA. Read the court ruling.
|5. Job Opportunties
Seeking a job? Have a job opening? Visit the ISSCR’s Job Bank. ISSCR members receive a discount on job postings.
Featured Job Posting. Now you can feature your job opening both on the ISSCR Job Bank and in the ISSCR’s monthly e-newsletter, The Pulse. Our e-newsletter is sent to more than 14,000 professionals in the stem cell field, so take advantage of this additional exposure!
|7. Meetings and Courses
ISSCR Meetings and Events
4th International Conference on Stem Cell Engineering
Regional Forum Series 2014
Co-presented by the Society for Biological Engineering and the ISSCR
March 16 - 19, 2014
Coronado, California, USA
Abstract Submission Deadline: December 10, 2013
ISSCR 12th Annual Meeting
Co-Sponsored by STEMCELL Technologies
June 18 - 21, 2014
Global Controls in Stem Cells
Regional Forum Series 2014
Co-organized by ISSCR and Stem Cell Society Singapore
November 5-7, 2014
Stem Cell Meetings
CHI's Targeting Cancer Stem Cells: New Opportunities for Oncology Therapeutics
February 13 - 14, 2014
San Francisco, CA, USA
February 17 - 19, 2014
London, United Kingdom
Stanford Cardiovascular Regenerative Medicine Symposium
February 28, 2014
Li Ka Shing Center
Palo Alto, CA, USA
Gordon Research Conference on "Reprogramming Cell Fate"
March 2 – 7, 2014
Galveston, TX, USA
Single Cell Analysis Europe 2014
March 10 - 11, 2014
Poster Presentation Submission Deadline: February 11, 2014
Keystone Symposia: Stem Cells and Reprogramming
April 6 - 11, 2014
Olympic Valley, California
Registration Closes: April 6, 2014
9th Annual Wisconsin Stem Cell Symposium: from Stem Cells to Blood
April 30, 2014
BioPharmaceutical Technology Center, Promega Campus
Hotel Discount Deadline: March 29, 2014
Poster Presentation Submission Deadline: April 9, 2014
NextGen Stem Cell Meeting
May 7 - 8, 2014
Saratoga, NY, USA
Discounted Registration Deadline: March 10, 2014
Keystone Symposia: Adult Neurogenesis
May 12 - 17, 2014
Late Abstract Submission Deadline: February 13, 2014
Discounted Registration Deadline: March 12, 2014
The Stem Cell Niche
May 18 - 22, 2014
May 29 - 30, 2014
New York, NY USA
Abstract Submission Deadline: March 7, 2014
Upcoming Stem Cell Courses
Human ES/iPS Cell Research
March 25 - 28, 2014
MACS Academy, Miltenyi Biotec
Bergisch Gladbach/Cologne, Germany
View a list of recurring courses and seminar/meeting series.
|8. Literature Highlights
Stem Cell Reports
The February 11 issue of the ISSCR's online, open=access journal, Stem Cell Reports is now available. Read about the highlights from this issue here and visit the Stem Cell Reports website or click the citations below to read each individual paper.
New articles are available every week online
About the cover. This month's cover features the dentate gyrus of a GFP reporter mouse one month after receiving an injection of a Cre retrovirus followed by an exercise regimen. GFAP-labeled astrocytes appear in red, doublecortin-positive neuroblasts appear in white.
|Read the paper
Beckervordersandforth, R., Deshpande, A., Schäffner, I., Huttner, H.B., Lepier, A., Lie, D.C., and Götz, M. (2014). In Vivo Targeting of Adult Neural Stem Cells in the Dentate Gyrus by a Split-Cre Approach. Stem Cell Reports 2, 153-162.
Read the complete table of contents.
Focus on STAP Cells
Two articles published in the January 30, 2014, issue of Nature describe the induction of a pluripotent state in neonatal mouse cells through exposure to various stresses, including a short exposure to a low pH environment. Read the ISSCR statement.
|Read the papers
Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M.P., Niwa, H., Yamato, M., and Vacanti, C.A. (2014). Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature 505, 641–647.'
Obokata, H., Sasai, Y., Niwa, H., Kadota, M., Andrabi, M., Takata, N., Tokoro, M., Terashita, Y., Yonemura, S., Vacanti, C.A., et al. (2014). Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature 505, 676–680.
|Read the commentary
Smith, A. (2014). Cell biology: Potency unchained. Nature 505, 622–623.
Zon, L. (2014). Translational Research: The Path for Bringing Discovery to Patients. Cell Stem Cell 14, 146–148.
Lu, J., Bradley, R.A., and Zhang, S.-C. (2014). Turning Reactive Glia into Functional Neurons in the Brain. Cell Stem Cell 14, 133–134.
Refers to Guo et al., 2014.
Shivdasani, R.A. (2014). Radiation Redux: Reserve Intestinal Stem Cells Miss the Call to Duty. Cell Stem Cell 14, 135–136.
Refers to Metcalfe et al., 2014.
Davis-Dusenbery, B.N., Williams, L.A., Klim, J.R., and Eggan, K. (2014). How to make spinal motor neurons. Development 141, 491–501.
Koo, B.-K., Sasselli, V. and Clevers, H. (2013). Retroviral Gene Expression Control in Primary Organoid Cultures. Curr Protoc Stem Cell Biol. 27:5A.6.1–5A.6.8.
Carter, A.C., Davis-Dusenbery, B.N., Koszka, K., Ichida, J.K., and Eggan, K. (2014). Nanog-Independent Reprogramming to iPSCs with Canonical Factors. Stem Cell Reports 2, 119–126.
De, D., Jeong, M.-H., Leem, Y.-E., Svergun, D.I., Wemmer, D.E., Kang, J.-S., Kim, K.K., and Kim, S.-H. (2014). Inhibition of master transcription factors in pluripotent cells induces early stage differentiation. Proc Nat Acad Sci USA 111, 1778–1783.
Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., and Chen, G. (2014). In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell 14, 188–202.
Jayaram, H., Jones, M.F., Eastlake, K., Cottrill, P.B., Becker, S., Wiseman, J., Khaw, P.T., and Limb, G.A. (2014). Transplantation of Photoreceptors Derived From Human Muller Glia Restore Rod Function in the P23H Rat. Stem Cells Transl Med. doi:10.5966/sctm.2013-0112
Kamao, H., Mandai, M., Okamoto, S., Sakai, N., Suga, A., Sugita, S., Kiryu, J., and Takahashi, M. (2014). Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application. Stem Cell Reports 2, 205–218.
Koga, M., Matsuda, M., Kawamura, T., Sogo, T., Shigeno, A., Nishida, E., and Ebisuya, M. (2014). Foxd1 is a mediator and indicator of the cell reprogramming process. Nat Commun 5. doi:10.1038/ncomms4197
Lee, J.-H., Bhang, D.H., Beede, A., Huang, T.L., Stripp, B.R., Bloch, K.D., Wagers, A.J., Tseng, Y.-H., Ryeom, S., and Kim, C.F. (2014). Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis. Cell 156, 440–455.
Li, K., Zhu, S., Russ, H.A., Xu, S., Xu, T., Zhang, Y., Ma, T., Hebrok, M., and Ding, S. (2014). Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages. Cell Stem Cell 14, 228–236.
Lien, W.-H., Polak, L., Lin, M., Lay, K., Zheng, D., and Fuchs, E. (2014). In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol 16, 179–190.
Machado, C.B., Kanning, K.C., Kreis, P., Stevenson, D., Crossley, M., Nowak, M., Iacovino, M., Kyba, M., Chambers, D., Blanc, E., and Lieberam, I. (2014). Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development 141, 784–794.
Merkle, F.T., Fuentealba, L.C., Sanders, T.A., Magno, L., Kessaris, N., and Alvarez-Buylla, A. (2014). Adult neural stem cells in distinct microdomains generate previously unknown interneuron types. Nat. Neurosci. 17, 207–214.
Metcalfe, C., Kljavin, N.M., Ybarra, R., and de Sauvage, F.J. (2014). Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration. Cell Stem Cell 14, 149–159.
Mikhailova, A., Ilmarinen, T., Uusitalo, H., and Skottman, H. Small-Molecule Induction Promotes Corneal Epithelial Cell Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports.
Miyaoka, Y., Chan, A.H., Judge, L.M., Yoo, J., Huang, M., Nguyen, T.D., Lizarraga, P.P., So, P.-L., and Conklin, B.R. (2014). Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nat Methods. doi:10.1038/nmeth.2840.