|This issue is sponsored by:|
|1. Editor's Message
Carl Wonders, PhD
ISSCR 12th Annual Meeting, June 18-21, 2014, Vancouver, Canada. Deadlines are fast approaching for both Abstract Submission and Early Registration! Read about these important dates and more about the meeting in Section 2.
Announcing the 2014 ISSCR Award Winners. The ISSCR congratulates the winners of the 2014 McEwen Award for Innovation, the ISSCR-BD Biosciences Outstanding Young Investigator Award and the ISSCR Public Service Award. Learn more about the winners in Section 3.
ISSCR Connect. Beginning this February, ISSCR Connect will feature two new programming series and a new and improved look! See Section 4 to read more.
Introducing the ISSCR Member Spotlight Series. Get to know your fellow ISSCR members through our new Spotlight Series, appearing monthly on the ISSCR website. We are over 4,100 members across 55+ countries; let’s make our world just a little bit smaller one member at a time. Click here to meet Dr. Yukiko Yamashita.
2014 ISSCR Elections. The 2014 elections for the ISSCR Board of Directors will open February 6. Find out more about the elections and view the slate of candidates. Have you renewed your membership for 2014? Only members who have paid this year's dues will be eligible to vote. Don't miss out on this opportunity to help shape the future of the ISSCR! Renew your membership today and continue your commitment to advancing the stem cell field and engaging in the global stem cell community. Easily pay by credit card, check, or wire, and save 5% by renewing for three years using the new online form. Not yet a member? Join today!
“I am a member because I believe in our collaborative power to propel stem cell research. Please join me in renewing your commitment to the science, education, and public outreach of the ISSCR.”
– Janet Rossant, PhD, ISSCR President
4th International Conference on Stem Cell Engineering, March 16-19, 2014, Coronado, California, USA. Co-presented by the Society for Biological Engineering and the ISSCR. This meeting brings together biologists, engineers and clinicians who are working on cellular therapies to accelerate progress in designing the stem cell and its environment. Learn more about this meeting.
Sponsor The Pulse and Get Noticed. Promote your products and services to more than 14,000 members of the stem cell community by being an exclusive sponsor of The Pulse. Openings for 2014 issues are available. For information about sponsorship, contact Amy Claver.
|2. ISSCR 12th Annual Meeting
ISSCR 12th Annual Meeting
June 18-21, 2014
Vancouver, British Columbia, Canada
Co-sponsored by STEMCELL Technologies
|Abstract Submission Deadline:
||February 11, 2014
|Early Registration Deadline:
||February 28, 2014
Registration and Abstract Submission are now open!
Learn about the latest research across the breadth of stem cell research, from early development to clinical applications by registering for the Annual Meeting. Early Registration ends February 28, so register today to receive the best registration rate and to be entered to win a seaplane tour of Vancouver. Read more about the scientific program and find information about traveling to Vancouver on the Annual Meeting website.
Share your work and be a part of the scientific program by submitting an abstract. We select our concurrent speakers from the abstracts that we receive. Submitting your latest research also makes you eligible to apply for an ISSCR Travel Award, and Trainee Members can also elect to be considered for a Poster Award. The deadline to submit an abstract is February 11.
Discover more ways to network with colleagues and additional perspectives on stem cell science by participating in our Wednesday morning sessions and Junior Investigator networking events.
Travel Awards are available. When you submit an abstract, elect to be considered for a travel award, which will cover your registration and help to defray the cost of traveling to Vancouver.
Poster Awards. Trainee members who present posters at the Annual Meeting can elect to be judged for a Poster Award. The six 2013 winners received complimentary registration to the 2014 Annual Meeting, a one-year subscription to Cell Stem Cell and Current Protocols in Stem Cell Biology and a cash stipend. In addition, each was given the opportunity to present their poster as a 10-minute talk on ISSCR Connect, which were made available to all registrants of the 2013 Annual Meeting last August.
Junior Investigator Networking Events. Each year, Junior Investigators have the opportunity to attend specific networking, career-building and social events. Details of these events are still being finalized, with details on the Meet the Experts Lunches and JI Career Panel coming soon on our website.
Arrive early and attend the Wednesday pre-meeting events.Focus Sessions and Industry Wednesday Symposia are offered the Wednesday morning before the start of the Annual Meeting as a way of allowing members, non profit-organizations and companies to extend the range of topics being covered.
Help us spread the word! Download the ISSCR 12th Annual Meeting PowerPoint® slide for use in your next presentation.
Visit our co-sponsor, STEMCELL Technologies.
|3. 2014 ISSCR Awards
The ISSCR announces its 2014 Award winners. Each year, the ISSCR is proud to offer awards in recognition of excellent research in and support of the fields of stem cell research and regenerative medicine. We congratulate the winners, who will be presented with their awards at the ISSCR 12th Annual Meeting in Vancouver, Canada.
||The 2014 McEwen Award for Innovation will be presented to Azim Surani, PhD, Wellcome Trust/Cancer Research UK Gurdon Institute, in recognition of his work on the cellular and molecular specification of the mammalian germ cell lineage. His research has helped uncover how the germ line is established and what molecular mechanisms are responsible for reprogramming the epigenome to achieve the totipotent state. Dr. Surani will be presented with his award during the Presidential Symposium on Wednesday, June 18, 2014.
||The 2014 ISSCR-BD Biosciences Outstanding Young Investigator Award will be presented to Valentina Greco, PhD, Yale University, for her research into the interactions between stem cells and their niches, including the first direct, real-time visualization of stem cell divisions in living animals. Dr. Greco will be presented with her award and present her talk during Plenary V on Saturday, June 21, 2014.
|The 2014 ISSCR Public Service Award will be presented to Paolo Bianco, MD, Sapienza University of Rome, Elena Cattaneo, PhD, University of Milan, and Michele De Luca, MD, University of Modena and Reggio Emilia, in recognition of their recent involvement in public debate and policy-making in Italy and their championing of rigorous scientific and medical standards and stringent regulatory oversight in the introduction of new stem cell treatments into the clinic. This award will be presented during the Presidential Symposium on Wednesday, June 18, 2014.
Learn more about the awards and this year’s winners on the ISSCR website.
|4. ISSCR Connect
ISSCR Connect is our online, educational and interactive portal that provides ongoing learning opportunities and the ability to make connections and open new avenues of communication in our fast moving field throughout the year.
Available to all, the ISSCR Connect Public Channel features news and other general information about stem cells and the ISSCR. If you are not a member of the ISSCR and would like an account on ISSCR Connect, fill out our online registration form .
What's New at the ISSCR – Broadcasting monthly, "What's New at the ISSCR" discusses the latest developments within the ISSCR. Hear about new ISSCR programs, bring your questions and participate using the live chat and Q&A features!
The program begins at 10 am ET (USA).
Can't make it? The program will be available on-demand after the broadcast
As an ISSCR member benefit, the ISSCR Connect Members Channel provides additional educational opportunities through scientific presentations and other programming. All ISSCR members automatically receive an ISSCR Connect account with access to the Members and Public Channels.
January concludes our two series featuring previous winners of the ISSCR Outstanding Young Investigator Award (OYIA) and focusing on neural stem cells. Joanna Wysocka will give the final presentation in the (OYIA), while the last talk in our neural series was given by Fred H. Gage on January 7 and is available on demand through January 21.
In February, we will begin a new program series entitled Building Organs with Stem Cells with a second new series, Stem Cells and Cancer, beginning in March.
||Joanna Wysocka, PhD, will present the concluding talk in our series featuring previous OYIA winners. Her talk, entitled "Stem Cells, Enhancers and the Emergence of Epigenomes in Development" will be given on January 22 at 2 pm ET (USA).
Charles Murry, MD, PhD, will kick-off our new series, Building Organs with Stem Cells on February 6 with a talk entitled “Heart Regeneration”
Dr. Murry's talk will begin at 4 pm ET (USA).
Meritxell Huch, PhD, will present the next talk in this series, entitled “Lgr5 Stem Cells of the Gastrointestinal Tract: Organoid Cultures and Regenerative Medicine” on February 19.
Dr. Huch's presentation will begin at 11 am ET (USA)
Exciting Changes are coming to ISSCR Connect!
This February, we will be unveiling a new look and feel for ISSCR Connect. We are continuing to grow and add new lectures and series, and our new platform will make it even easier to navigate and discover new talks and other programs. Look for more information coming next month!
|5. Job Opportunities
Seeking a job? Have a job opening? Visit the ISSCR’s Job Bank. ISSCR members receive a discount on job postings.
Featured Job Posting. Now you can feature your job opening both on the ISSCR Job Bank and in the ISSCR’s monthly e-newsletter, The Pulse. Our e-newsletter is sent to more than 14,000 professionals in the stem cell field, so take advantage of this additional exposure!
|7. Meetings and Courses
ISSCR Meetings and Events
4th International Conference on Stem Cell Engineering
Regional Forum Series 2014
Co-presented by the Society for Biological Engineering and the ISSCR
March 16 - 19, 2014
Coronado, California, USA
Abstract Submission Deadline: December 10, 2013
ISSCR 12th Annual Meeting
Co-Sponsored by STEMCELL Technologies
June 18 - 21, 2014
Global Controls in Stem Cells
Regional Forum Series 2014
Co-organized by ISSCR and Stem Cell Society Singapore
November 5-7, 2014
Stem Cell Meetings
CiRA International Symposium 2013
January 17, 2014
Associated with The 7th Takeda Science Foundation Symposium on PharmaSciences (Jan 16 - 18, 2014)
Keystone Symposia: Stem Cells and Cancer
February 2 - 7, 2014
Banff, Alberta, Canada
Discounted Registration Deadline: February 2, 2014
CHI's Targeting Cancer Stem Cells: New Opportunities for Oncology Therapeutics
February 13 - 14, 2014
San Francisco, CA, USA
February 17 - 19, 2014
London, United Kingdom
Single Cell Analysis Europe 2014
March 10 - 11, 2014
Discounted Registration Deadline: January 27, 2014
Poster Presentation Submission Deadline: February 11, 2014
Keystone Symposia: Stem Cells and Reprogramming
April 6 - 11, 2014
Olympic Valley, California
Abstract Submission Deadline: January 15, 2014
Discounted Registration Deadline: February 6, 2014
Registration Closes: April 6, 2014
Keystone Symposia: Adult Neurogenesis
May 12 - 17, 2014
Late Abstract Submission Deadline: February 13, 2014
Discounted Registration Deadline: March 12, 2014
The Stem Cell Niche
May 18 - 22, 2014
May 29 - 30, 2014
New York, NY USA
Registration Opens: January 2014
Abstract Submission Deadline: March 7, 2014
Upcoming Stem Cell Courses
Human ES/iPS Cell Research
March 25 - 28, 2014
MACS Academy, Miltenyi Biotec
Bergisch Gladbach/Cologne, Germany
View a list of recurring courses and seminar/meeting series.
|8. Literature Highlights
Stem Cell Reports
The January 14 issue of the ISSCR's online, open-access journal, Stem Cell Reports, is now available. Read about the highlights from this issue here and visit the Stem Cell Reports website or click the citations below to read each individual paper.
New articles are available online every week!
About the cover. This month's cover is an artistic representation of how antioxidants can help prevent genomic aberrations that can occur during the process of reprogramming.
|Read the paper
Ji, J., Sharma, V., Qi, S., Guarch, M.E., Zhao, P., Luo, Z., Fan, W., Wang, Y., Mbabaali, F., Neculai, D., et al. (2014). Antioxidant Supplementation Reduces Genomic Aberrations in Human Induced Pluripotent Stem Cells. Stem Cell Reports 2, 44–51.
Read the complete table of contents.
ISSCR Meeting Reports. Read the highlights from the ISSCR 11th Annual Meeting (Boston, MA, USA) and the ISSCR Regional Forum Stem Cells in Translation (Florence, Italy)
Dasgupta, I., Bollinger, J., Mathews, D.J.H., Neumann, N.M., Rattani, A., and Sugarman, J. (2014). Patients’ Attitudes toward the Donation of Biological Materials for the Derivation of Induced Pluripotent Stem Cells. Cell Stem Cell 14, 9–12.
Abbott, A. (2014). Leaked files slam stem-cell therapy. Nature News 505, 139–140.
Gouon-Evans, V. (2014). The Race for Regeneration: Pluripotent-Stem-Cell-Derived 3D Kidney Structures. Cell Stem Cell 14, 5–6.
Refers to Taguchi et al., 2014
Humphreys, B.D. (2014). Kidney structures differentiated from stem cells. Nature Cell Biology 16, 19–21.
Refers to Takasato et al., 2014
Mascetti, V.L., and Pedersen, R.A. (2014). Naivete of the human pluripotent stem cell. Nature Biotechnology 32, 68–70.
Refers to Gafni et al., 2013
Magnúsdóttir, E., and Surani, M.A. (2014). How to make a primordial germ cell. Development 141, 245–252.
Ankrum, J.A., Miranda, O.R., Ng, K.S., Sarkar, D., Xu, C., and Karp, J.M. (2014). Engineering cells with intracellular agent-loaded microparticles to control cell phenotype. Nature Protoc 9, 233–245.
Warren, L. and Wang, J. 2013. Feeder-Free Reprogramming of Human Fibroblasts with Messenger RNA. Curr Protoc Stem Cell Biol 27:4A.6.1–4A.6.27.
Chen, K.G., Mallon, B.S., McKay, R.D.G., and Robey, P.G. (2014). Human Pluripotent Stem Cell Culture: Considerations for Maintenance, Expansion, and Therapeutics. Cell Stem Cell 14, 13–26.
Brumbaugh, J., Russell, J.D., Yu, P., Westphall, M.S., Coon, J.J., and Thomson, J.A. (2014). NANOG Is Multiply Phosphorylated and Directly Modified by ERK2 and CDK1 In Vitro. Stem Cell Reports 2, 18–25.
Castiglioni, A., Hettmer, S., Lynes, M.D., Rao, T.N., Tchessalova, D., Sinha, I., Lee, B.T., Tseng, Y.-H., and Wagers, A.J. (2014). Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle. Stem Cell Reports 2, 92–106.
Gafni, O., Weinberger, L., Mansour, A.A., Manor, Y.S., Chomsky, E., Ben-Yosef, D., Kalma, Y., Viukov, S., Maza, I., Zviran, A., et al. (2013). Derivation of novel human ground state naive pluripotent stem cells. Nature 504, 282–286.
Huang, S.X.L., Islam, M.N., O'Neill, J., Hu, Z., Yang, Y.-G., Chen, Y.-W., Mumau, M., Green, M.D., Vunjak-Novakovic, G., Bhattacharya, J., et al. (2014). Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32, 84–91.
Juliano, C.E., Reich, A., Liu, N., Gotzfried, J., Zhong, M., Uman, S., Reenan, R.A., Wessel, G.M., Steele, R.E., and Lin, H. (2014). PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proceedings of the National Academy of Sciences 111, 337–342.
Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., et al. (2014). A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells. Sci Rep 4, 3594.
Sarkar, S., Döring, A., Zemp, F.J., Silva, C., Lun, X., Wang, X., Kelly, J., Hader, W., Hamilton, M., Mercier, P., et al. (2014). Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci 17, 46–55.
Taguchi, A., Kaku, Y., Ohmori, T., Sharmin, S., Ogawa, M., Sasaki, H., and Nishinakamura, R. (2014). Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells. Cell Stem Cell 14, 53–67.
Takasato, M., Er, P.X., Becroft, M., Vanslambrouck, J.M., Stanley, E.G., Elefanty, A.G., and Little, M.H. (2014). Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol 16, 118–126.
Worringer, K.A., Rand, T.A., Hayashi, Y., Sami, S., Takahashi, K., Tanabe, K., Narita, M., Srivastava, D., and Yamanaka, S. (2014). The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes. Cell Stem Cell14, 40–52.