|This issue is sponsored by:|
|1. Editor's Message
Carl Wonders, PhD
ISSCR 12th Annual Meeting, Vancouver, British Columbia, Canada. This June 18-21, 2014, the ISSCR will be in the beautiful city of Vancouver for the ISSCR 12th Annual Meeting. Abstract submission and registration will both open on December 12. See Section 2 for more information.
Stem Cell Therapies: Opportunities for Assuring the Quality and Safety of Unregulated Clinical Offerings. The ISSCR, along with the Institute of Medicine and the National Academy of Sciences, is hosting a workshop and live webcast examining the practice and consequences of unproven stem cell treatments on November 18, 2013 from 8:30 a.m.-5:30 p.m. EDT in Washington. DC, USA. The workshop/webcast is free, and registration is open to the public here. The live webcast will be available on-demand following the event.
ISSCR Connect. For the month of November, we continue our series highlighting our previous Outstanding Young Investigator Award winners and our neural stem cell series. For more information on upcoming programs, see Section 3.
4th International Conference on Stem Cell Engineering, March 16-19, 2014, Coronado, California, USA. Co-presented by the Society for Biological Engineering (SBE) and the ISSCR. This meeting aims to bring together biologists, engineers and clinicians who are working on cellular therapies to accelerate progress towards designing the stem cell and its environment. Abstract submission is now open through December 10, 2013. Read more.
The ISSCR is accepting proposals from Asia-Pacific-based organizations interested in co-sponsoring our 16th Annual Meeting in June 2018. The ISSCR Annual Meeting is a forum for discussion and dissemination of groundbreaking research in all areas of stem cell science and translation, drawing participants from academic, industry, ethics and government settings all over the world. Learn more.
Easy Paperless Membership Application & Renewal. It is now easier than ever to join the ISSCR and maintain your membership with our new online system. Help us improve ISSCR programs by providing information about the topics that most interest you. New applicant endorsements are now managed quickly and efficiently online.
|Sponsor The Pulse and Get Noticed. Promote your products and services to more than 14,000 members of the stem cell community by being an exclusive sponsor of The Pulse. Openings for 2014 issues are available. For information about sponsorship, contact Amy Claver.
|2. ISSCR 12th Annual Meeting
ISSCR 12th Annual Meeting
June 18-21, 2014
Co-sponsored by STEMCELL Technologies
In 2014, the ISSCR will return to Canada as the beautiful city of Vancouver, British Columbia plays host to the ISSCR 12th Annual Meeting.
Registration and Abstract Submission open December 12. This year's program features 7 plenary and 20 concurrent sessions with topics covering the full breadth of stem cell research. View the updated preliminary schedule, list of confirmed speakers and our Featured Speakers.
Travel awards are available. When submitting your abstract, apply to be considered for a travel award. These awards will cover the cost of your registration to the meeting and include a stipend to help defray the costs of traveling to Vancouver.
Plan to arrive early! Each year, the ISSCR offers Focus Sessions and Industry Wednesday Symposia the morning before the start of the Annual Meeting. These sessions provide opportunities for members, non-profit organizations and companies to extend the range of topics covered by the meeting.
- Focus Sessions are member-organized presentations that offer parallel, in-depth educational opportunities and explore unique issues relating to stem cell research. To date, two Focus Sessions are currently being developed, and information about their programs will be available on the ISSCR website soon.
Ethics, Stem Cells and the Information Age – presented by the ISSCR Ethics and Public Policy Committee
Engaging the Engine - How Public/Private Partnerships Between Academia and Industry Can Facilitate More Efficient Translation – presented by the ISSCR Industry and Junior Investigator Committees.
If you are interested in proposing a Focus Session to add to the 2014 pre-meeting program, an RFP will be available online soon.
- Industry Wednesday Symposia sessions give companies the opportunity to present topical scientific issues in stem cell science as framed by industry leaders. If your company is interested in participating or would like more information, contact Amy Claver or Drew Rich today!
Help spread the word! Download the ISSCR 12th Annual Meeting PowerPoint® slide for use in your next presentation.
Visit our co-sponsor, STEMCELL Technologies.
|3. ISSCR Connect
ISSCR Connect is an online, educational and interactive portal that provides learning opportunities and the ability to make connections and open new avenues of communication in our fast-moving field throughout the year.
November's programming lineup includes our monthly What's New in the ISSCR new update, Arnold Kriegsteingives the second talk in our neural stem cell series and Konrad Hochedlinger's presentation from earlier this month will be available on-demand until November 20.
Available to all, the ISSCR Connect Public Channel features news and other general information about stem cells and the ISSCR. If you are not a member of the ISSCR and would like an account on ISSCR Connect, fill out our online registration form .
What's New at the ISSCR – Broadcasting monthly, "What's New at the ISSCR" discusses the latest developments within the ISSCR. Hear about new ISSCR programs, bring your questions and participate using the live chat and Q&A features!
The program begins at 10 am ET (USA). Calculate your local time
Can't make it? The program will be available on-demand after the broadcast
As an ISSCR member benefit, the ISSCR Connect Members Channel provides additional educational opportunities through scientific presentations and other programming. All ISSCR members automatically receive an ISSCR Connect account with access to the Members and Public Channels.
|Having trouble accessing your account? Email Carl Wonders for help.
||If you missed last week's presentation by Konrad Hochedlinger, the inaugural recipient of the ISSCR Outstanding Young Investigator Award, his talk is available on -demand to all ISSCR members through Wednesday, November 20. Click here to access this presentation (login required).
Arnold Kriegstein, MD, PhD will present the next talk in our series focusing on neural stem cells. His presentation, entitled “Neural Stem and Progenitor Cells to Model Human Cortical Development” will begin at 2 pm Eastern Time (USA) on November 20, 2013.
Click here to be taken directly to the presentation page.
||Jürgen Knoblich, PhD, will present on December 11 at 10 am ET (USA), and the title of his talk will be "Modeling Early Human Brain Development in 3D Culture." Click here to be taken to the presentation page, where you can add the event to your calendar.
Coming in 2014: in the early months of 2014, we will be beginning two new series focusing on Stem Cells and Cancer and Building Organs with Stem Cells. Speaker information will be available on the the ISSCR website and on ISSCR Connect once it is finalized.
|4. News Roundup
California, USA. On October 16, the California Institute for Regenerative Medicine (CIRM) announced that current president Alan Trounson would be stepping down from the position. Trounson will remain president until his successor can be identified. Read more.
California, USA. On November 4, the University of California, San Diego announced the gift of $100 million from philanthropist T. Denny Sanford for the creation of the Sanford Stem Cell Clinical Center, which has a mission to accelerate the development of drugs and cell therapies inspired by and derived from current human stem cell research. Read more.
Italy. On October 10, Italy’s Minister of Health Beatrice Lorenzin announced that the unproven stem cell therapy developed by the Stamina Foundation could not be tested on humans in Italy within the context of a clinical trial. Read more.
|5. Job Opportunities
Seeking a job? Have a job opening? Visit the ISSCR’s Job Bank. ISSCR members receive a discount on job postings.
Featured Job Posting. Now you can feature your job opening both on the ISSCR Job Bank and in the ISSCR’s monthly e-newsletter, The Pulse. The e-newsletter is sent to more than 14,000 professionals in the stem cell field, so take advantage of this additional exposure!
|7. Meetings and Courses
Stem Cell Meetings
Cell Symposia: Using Stem Cells to Model and Treat Human Disease
November 21-23, 2013
Los Angeles, California, USA3
Innovating the Marketplace with Stem Cells
November 29, 2013
Convention Centre, Darling Harbour
The 6th Annual Maryland Stem Cell Research Symposium
December 3, 2013
Johns Hopkins Medical Campus
Baltimore, MD, USA
2013 World Stem Cell Summit
December 4 - 6, 2013
San Diego, CA USA
Annual Symposium - Biochemical Determinants of Tissue Regeneration
December 11 - 13, 2013
Shrigley Hall Hotel
2013 American Society for Cell Biology Annual Meeting
December 14 - 18, 2013
New Orleans, LA USA
The 7th Takeda Science Foundation Symposium on PharmaSciences
January 16 - 18, 2014
Associated with the CiRA International Symposium 2014
Keystone Symposia: Stem Cells and Cancer
February 2 - 7, 2014
Banff, Alberta, Canada
Discounted Registration Deadline: December 3, 2013
February 17 - 19, 2014
London, United Kingdom
Keystone Symposia: Stem Cells and Reprogramming
April 6 - 11, 2014
Olympic Valley, California
Scholarship Application Deadline: December 10, 2013
Abstract Submission Deadline: January 15, 2014
Discounted Registration Deadline: February 6, 2014
Registration Closes: April 6, 2014
Upcoming Stem Cell Courses
Rehabilitative & Regenerative Medicine for Minority Health & Health Disparities
December 3 – 9, 2013
Washington, DC, USA
Practical Workshop – Pluripotent Stem Cell Technology
December 9 - 11, 2013
University of Oxford
Oxford, United Kingdom
Frontiers in Stem Cells in Cancer
December 8 - 13, 2013
Washington, DC, USA
Application Deadline: November 4, 2013
Scholarship Application Deadline: November 4, 2013
Stem Cells: A Pathway Through the Maze
December 11 - 13, 2013
Oxford, United Kingdom
Application Deadline: December 9, 2013
View a list of recurring courses and seminar/meeting series.
|8. Literature Highlights
Stem Cell Reports
The October 15 issue of the ISSCR's online, open-access journal, Stem Cell Reports, is now available. Read about the highlights from this issue here and visit the Stem Cell Reports website or click the citations below to read each individual paper.
New articles are available every week online, and the November issue is just around the corner!
Current Issue Highlights
The use of treatments derived from induced pluripotent stem cells (iPSCs) has attracted considerable attention. In this issue's paper by Morizane et al., HLA-matched and mismatched iPSCs were evaluated for their potential to cause an immune response, and the paper's findings are critical to our understanding of how to best proceed with iPSC-based treatments.
About the cover. This month's cover shows crystal violet-stained colony of mouse embryonic stem cells (ESCs) treated with L-Proline (PiCs), which nduces a fully reversible embryonic-stem-to-mesenchymal-like transition (esMT) that converts ESCs into highly motile and invasive pluripotent stem cells.
|Read the Paper
||Morizane, A., Doi, D., Kikuchi, T., Okita, K., Hotta, A., Kawasaki, T., Hayashi, T., Onoe, H., Shiina, T., Yamanaka, S. and Takahashi, J. (2013). Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate. Stem Cell Reports 1, 283-292.
||Rao, M. (2013). iPSC-based cell therapy: an important step forward. Stem Cell Reports 1, 281-282.
Read the complete table of contents.
|Read the paper
||Comes, S., Gagliardi, M., Laprano, N., Fico, A., Cimmino, A., Palamidessi, A., De Cesare, D., De Falco, S., Angelini, C., Scita, G., Patriarca, E. J., Metarazzo, M. R. and Minchiotti, G. (2013). L-proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation. Stem Cell Reports 1, 307-321.
Doulatov, S. and Daley, G. Q. (2013). A stem cell perspective on cellular engineering. Science 342, 700-702.
Cope, E. C. and Gould, E. (2013). Cytokines make an indelible impression on neural stem cells. Cell Stem Cell 13, 507-508.
Refers to Gallagher et al., 2013.
Malouf, C. and Ottersbach, K. (2013). The unconventional embryo: immune-restricted potential precedes multipotentiality. Cell Stem Cell 13, 509-510.
Refers to Böiers et al., 2013.
Reddien, P. W. (2013). Lin28: time for tissue repair. Cell 155, 738-739.
Refers to Shyh-Chang et al., 2013.
Silberstein, L. E. and Lin, C. P. (2013). A new image of the hematopoietic stem cell vascular niche. Cell Stem Cell 13, 514-516.
Refers to Kunisaki et al., 2013.
Joseph, C., Quach, J. M., Walkley, C. R., Lane, S. W., Lo Celso, C. and Purton, L. E. (2013). Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging systems. Cell Stem Cell 13, 520-533.
Wang, C. H., Ma, N., Lin, Y. T., Wu, C. C., Wu, H. J., Yu, C. C., Hsiao, M., Lu, F. L., Schuyler, S. C. and Lu, J. (2013). Array-Based High-Throughput Screening in Mouse Embryonic Stem Cells with shRNAs. Curr Protoc Stem Cell Biol 26:5C.3.1–5C.3.19.
Vilchez, D., Simic, M. S. and Dillin, A. (2013). Proteostasis and aging of stem cells. Trends Cell Biol doi:10.1016/j.tcb.2013.09.002.
Böiers, C., Carrelha, J., Lutteropp, M., Luc, S., et al. (2013). Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells. Cell Stem Cell 13, 535-548.
Denholtz, M., Bonora, G., Chronis, C., Splinter, E., de Laat, W., Ernst, J., Pellegrini, M. and Plath, K. (2013). Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell 13, 602-616.
Feinberg, A. W., Ripplinger, C. M., van der Meer, P., Sheehy, S. P., Domain, I., Chien, K. R. and Parker, K. K. (2013). Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports doi:10.1016/j.stemcr.2013.10.004
Gafni, O., Weinberger, L., Mansour, A. A., Manor, Y. S., et al. (2013). Derivation of novel human ground state naïve pluripotent stem cells. Nature doi:10.1038/nature12745
Gallagher, D., Norman, A. A., Woodard, C. L., Yang, G., Gauthier-Fisher, A., Fujitani, M., Vessey, J. P., Cancino, G. I., Sachewsky, N., Woltjen, K., Fatt, M. P., Morshead, C. M., Kaplan, D. R. and Miller, F. D. (2013). Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell 13, 564-576.
Hannan, N. R. F., Fordham, R. P., Syed, Y. A., Moignard, V., Berry, A., Bautista, R., Hanley, N. A., Jensen, K. B. and Vallier, L. (2013). Generation of multi potent foregut stem cells from human pluripotent stem cells. Stem Cell Reports 1, 293-306.
Joly, W., Chartier, A., Rojas-Rios, P., Busseau, I. and Simonelig, M. (2013). The CCR4 deadenylase acts with Nanos and Pumilo in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal. Stem Cell Reports doi:10.1016/j.stemcr.2013.09.007
Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J. C., Bergman, A. and Frenette, P. S. (2013). Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 502, 637-643.
McConnell, M. J., Lindberg, M. R., Brennand, K. J., Piper, J. C.. Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R. S., Vermeesch, J. R., Hall, I. M. and Gage, F. H. (2013). Mosaic copy number variation in human neurons. Science 342, 632-637.
Porlan, E., Morante-Redolat, J. M., Marqués-Torrejón, M. A., Andreu-Agulló, C., Carneiro, C., Gòmez-Ibarlucea, E., Soto, A., Vidal, A., Ferrón, S. R. and Feriñas, I. (2013). Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance. Nat Neurosci 16, 1567-1575.
Sabelström, H., Stenudd, M., Réu, P., Dias, D. O., Elfineh, M., Zdunek, S., Damberg, P., Göritz, C. and Frisén, J. (2013). Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science 342, 637-640.
Sahai-Hernandez, P. and Nystul, T. G. (2013). A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary. Development 140, 4490-4498.
Shyh-Chang, N., Zhu, H., de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. M., Nguyen, L., Asara, J. M., Cantlye, L. C. and Daley, G. Q. (2013). Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 155, 778-792.
Stange, D. E., Koo, B. K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, J. H., Peters, P. J., van Es, J. H., van de Wetering, M., Mills, J. C. and Clevers, H. (2013). Differentiated troy(+) chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155, 357-368.
Xu, C., Tabebordbar, M., Iovino, S., Ciarlo, C., Liu, J., Castiglioni, A., Price, E., Liu, M., Barton, E. R., Kahn, C. R., Wagers, A. J. and Zon, L. I. (2013). A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell 155, 909-921.