|This issue is sponsored by:|
|1. Editor's Message
Carl Wonders, PhD
ISSCR Regional Forum Series 2013. Over the next two months, the ISSCR will be hosting two Regional Forums as part of the ISSCR Regional Forum Series 2013. Designed to complement the Annual Meeting, Regional Forums provide additional opportunities to hear the latest findings and breakthroughs in stem cell research in your part of the world in a relaxed and participatory environment.
It's not too late to register for either of these events! Click on the above links for more information.
Save the date: ISSCR 12th Annual Meeting. Co-sponsored by STEMCELL Technologies, we will be returning to Canada for the ISSCR 12th Annual Meeting, June 18-21, 2014 in Vancouver, British Columbia. Abstract and registration will open in December. Visit the Annual Meeting Website for the latest information. See the list of featured speakers.
Fourth International Conference on Stem Cell Engineering. Be on the lookout for this meeting, presented by the Society for Biological Engineering and the ISSCR, coming in 2014. View the webpage for more information.
||ISSCR Connect. New programming for September includes the next "What's New in the ISSCR", a presentation by 2011 Outstanding Young Investigator Award-winner Robert Blelloch and presentations from three Poster Award winners from the ISSCR 11th Annual Meeting last June in Boston! See Section 4 for complete details!
ISSCR Membership Survey. In an effort to better meet the evolving needs of our members, we are asking for your opinions about your member benefits and your priorities and vision for the future of the ISSCR. On September 30, all ISSCR members will emailed the 2013 Membership Survey. We encourage you to share your opinions, and everyone who completes the survey will be entered into a drawing to win a free registration to their choice of the ISSCR Annual Meeting or a Regional Forum.
Online improvements coming for members. This October, we will be rolling out new features to our online services designed to improve customer service and ease of use, including an improved membership and dues application and a single-sign-on process across multiple web services and websites. Stay tuned for more information as we launch these services in the coming weeks.
Nominations are now open for two ISSCR Awards. Each year, the ISSCR honors innovative work done to harness the potential of stem cells and celebrates the achievements of an exceptional early career investigator. Nominations are now open for the following awards:
The McEwen Award for Innovation , supported by the McEwen Centre for Regenerative Medicine in Toronto, Canada, recognizes original thinking and ground-breaking research pertaining to stem cells or regenerative medicine that opens new avenues of exploration towards the understanding or treatment of human disease or affliction.
The ISSCR Outstanding Young Investigator Award recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research.
Nominations for both awards will be accepted through October 15, 2013. For more information, to view past winners or to submit your nominations, visit the ISSCR Awards webpage or email Glori Rosenson .
Call for nominations for the ISSCR Board of Directors. The ISSCR is soliciting nominations for international representatives for the board of directors with terms beginning June 2014. New board members will be elected to a three-year term and are eligible for an additional one-term appointment. Board members are expected to attend two board meetings per year (one held in conjunction with the ISSCR Annual Meeting), actively participate in the ISSCR Annual Meeting and other events and assume volunteer leadership positions within the society.
Nominations can be made by all current ISSCR members in good standing and should include the nominee's contact information. All eligible candidates will be reviewed by the ISSCR Nominating Committee for possible slating in the general membership election that will begin in February 2014. Email your nominations to ISSCR Executive Director/CEO Nancy Witty by midnight (CST) November 1, 2013.
Sponsor the Pulse and Get Noticed. Promote your products and services to more than 14,000 members of the stem cell community by being an exclusive sponsor of The Pulse. Openings for 2014 issues are available. For more information about sponsorship, contact Amy Claver .
|2. Florence 2013 Regional Forum
Stem Cells in Translation
September 15 - 18, 2013
The ISSCR will be in Florence, Italy for Stem Cells in Translation, September 15-18, 2013. The goal of this Regional Forum is to foster collaboration and facilitate discussion among the field's leading researchers about what is needed to translate stem cell research into cell and gene therapies. Learn more about the meeting, the science and the location on the Florence 2013 website.
|It's not too late to register! Online registration is available through September 14, and on-site registration begins September 15. Don't miss this chance to learn the latest findings from highly respected scientists in stem cell translation. Register online today and you will enjoy significant savings compared to the on-site rate.
|3. Suzhou 2013 Regional Forum
Stem Cells in Science and Medicine
Co-organized by Cold Spring Harbor Asia
October 14-17, 2013
The ISSCR is pleased to return to Suzhou and once again partner with Cold Spring Harbor Asia to present Stem Cells in Science and Medicine.
Special registration rates are available for students and groups. If you are a student who is interested in attending Stem Cells in Science and Medicine, be sure to take advantage of the student registration rate, which is available through the Cold Spring Harbor Asia conference page. If you are traveling in a group of five or more, special group rates are also available. Contact Selvis Morales for more information.
Don't miss this diverse program offering a wide range of stem cell topics including Stem Cells & Development, iPSCs and Reprogramming, Cancer Stem Cells and Therapy and more. View the complete list of sessions and confirmed speakers.
More details, including hotel and travel information, can be found on the Stem Cells in Science and Medicine website.
|4. ISSCR Connect
||ISSCR Connect is an online, educational and interactive portal that provides educational content,the ability to make connections and open new avenues of communication in our fast-moving field throughout the year.
Available to all, the ISSCR Connect Public Channel features news and other general information about stem cells and the ISSCR. If you are not a member of the ISSCR and would like an account on ISSCR Connect, fill out our online registration form .
What's New at the ISSCR – Broadcasting monthly every second Wednesday of the month, "What's New at the ISSCR" is monthly program discussing the latest developments within the ISSCR. Hear about new ISSCR programs, bring your questions and participate using the live chat and Q&A features!
The program begins at 10 am ET (USA). Calculate your local time
Can't make it? The program will be available on-demand after the broadcast
An ISSCR member benefit, the ISSCR Connect Members Channel provides additional educational opportunites through scientific presentations and other programming. All ISSCR members automatically receive an ISSCR Connect account with access to the Members and Public Channels. Not yet a member? Join today and gain access to this additional content.
Outstanding Young Investigator Award Winner Spotlight Series
Our series featuring the previous winners of the ISSCR-University of Pittsburgh Outstanding Young Investigator Award continues on September 23, with a presentation by Robert Blelloch. View the ISSCR Connect Members Channel webpage to see the complete schedule for this series.
MicroRNA Regulated Gene Networks in Pluripotency
Robert Blelloch, MD, PhD, University of California, San Francisco
Dr. Blelloch will present live on Monday, September 23 at 4 PM EDT (USA). Calculate your local time.
Spotlight on Neural Stem Cells
Over the next few months, we will be highlighting the field of neural stem cells. The first talk in this series will be given by Sebastian Jessberger, MD, PhD, on October 23. View the lineup of speakers below, and click on the presentation date to see your local time.
|Oct. 23, 2013, 10 am ET (USA)
Sebastian Jessberger, MD, PhD
U. Zurich, Switzerland
|Nov. 20, 2013, 2 pm ET (USA)
Arnold Kriegstein, MD, PhD
U C San Francisco, USA
|December (Date/Time TBA)
Jurgen Knoblich, PhD
|Jan. 7, 2014, 3 PM ET (USA)
Fred H. Gage, PhD
Salk Institute, USA
For the next two weeks starting Wednesday, September 11, we are pleased to feature three of our ISSCR Poster Award winners from the ISSCR 11th Annual Meeting, which took place last June in Boston, Massachusetts, USA. Each has taken their award-winning poster and presented it as a 10-minute talk. These three individuals represent the future of stem cell research, and we encourage you to watch their presentations. Anyone who registered for the ISSCR 11th Annual Meeting will have access to this exclusive content.
|Michelle I. Lin, PhD
Boston Children's Hospital, USA
Gladstone Institutes, USA
|Meng Zhao, PhD
Stowers Institute, USA
Having trouble logging in? Click here to reset your password. If you continue to have trouble, contact Carl Wonders for help.
|5. Job Opportunities
Whether you are seeking a job or have a position to fill, visit the ISSCR’s Job Bank. You have the option of making your job a “Featured Job” like those listed below. Featured Jobs benefit from increased exposure in The Pulse.
Featured Job: Assistant Professor, Department of Stem Cell and Regenerative Biology, Harvard University. This joint department between the Harvard Faculty of Arts and Sciences and the Harvard Medical School is seeking PhD scientists with demonstrated research interests in developmental and stem cell biology enabling regenerative biology and with an emphasis on organ system repair and regeneration. Read the full posting.
Featured Job: Two Principal Investigator positions in developmental and stem cell biology. The Developmental & Stem Cell Biology Program at The Hospital for Sick Children, Canada, invites applications for two PI positions with an academic appointment as an Assistant or Associate Professor at the University of Toronto. Read the full posting.
|7. Meetings and Courses
Stem Cell Meetings
NHLBI Symposium on Cardiovascular Regenerative Medicine
September 25-26, 2013
National Institutes of Health
Bethesda, Maryland, USA
Quantitative Single Cell Biology in Stem Cell Research
October 10 - 11, 2013
Ludwig Maximilians University
2013 Shanghai International Symposium on Cancer Stem Cells
Oct. 17 - 19, 2013
Tongji University, Shanghai, China
World Conference on Regenerative Medicine 2013
Oct. 23 - 25, 2013
TERMIS-AM 2013 Conference & Expo
November 10 - 13, 2013
Hyatt Regency Atlanta
Atlanta, Georgia, USA
Discounted Registration Deadline: September 15, 2013
First Annual Conference 2013 of the German Stem Cell Network (GSCN)
November 11 - 13, 2013
Abstract Submission Deadline: September 30, 2013
Discounted Registration Deadline: September 30, 2013
Registration Closes: October 31, 2013
Stem Cell Society Singapore Symposium 2013
November 18-19, 2013
Early Registration Deadline: August 31, 2013
Oral Presentation Submission Deadline: September 1, 2013
Poster Abstract Deadline: October 1, 2013
Online Registration Closes: November 4, 2013
3rd World Congress on Cell Science & Stem Cell Research
November 20 - 22, 2013
Baltimore, MD, USA
Cell Symposia: Using Stem Cells to Model and Treat Human Disease
November 21-23, 2013
Los Angeles, California, USA
Early Registration Discount Deadline: August 30, 2013
Innovating the marketplace with stem cells
November 29, 2013
Convention Centre, Darling Harbour
The 6th Annual Maryland Stem Cell Research Symposium
December 3, 2013
Johns Hopkins Medical Campus
Baltimore, MD, USA
Abstract Submission Deadline: October 8, 2013
2013 World Stem Cell Summit
December 4 - 6, 2013
San Diego, CA USA
Abstract Submission Deadline: October 29, 2013
Discounted Registration Deadline: October 29, 2013
Hotel Discount Deadline: November 8, 2013
2013 American Society for Cell Biology Annual Meeting
December 14 - 18, 2013
New Orleans, LA USA
Stem Cell Courses
EMBO Practical Course: Current methods in cell biology
Sept. 26 - Oct. 4, 2013
Current Protocols Webinar:
Stem Cell and Reprogramming Research Methods: Practical Considerations for Studies of Disease Including Culture Methods and Genetic Manipulation.
October 10, 2013
12-1 pm ET (USA)
MACS Academy: Human ES/iPS Cell Research
November 5 - 8, 2013
Bergisch Gladbach/Cologne, Germany
Stem Cells: A Pathway Through the Maze
Dec. 11 - 13, 2013
Oxford, United Kingdom
Application Deadline: December 9, 2013
For a list of regularly occurring courses and meeting/course series, visit the ISSCR events calendar webpage
|8. Literature Highlights
Stem Cell Reports
||The September 10 issue of the ISSCR's online, open-access journal, Stem Cell Reports, is now available. See some of the highlights from this issue here and visit the Stem Cell Reports website to see the complete table of contents.
About the cover: This month's cover features a human fibroblast contaning the cardiac-specific alpha-myosin heavy chain-mCherry reporter that has been reprogrammed into an induced cardiomyocyte-like cell (iCM) by defined factors. The report, written by Fu et al., also includes a video showing a 3D fly-through.
|Read the paper:
||Fu, J. D., Stone, N. R., Liu, L., Spencer, C. I., Qian, L., Hayashi, Y., Delgado-Olguin, P., Ding, S., Bruneau, B. G. and Srivastava, D. (2013). Direct reprogramming of human fibroblasts toward a cardiac-like state. Stem Cell Reports 1, 235-247.
Bennicelli, J. L. and Bennett, J. (2013). Stem cells set their sights on retinitis pigmentosa. eLife 2013;2:e01291.
Refers to Tucker et al., 2013
LaBarge, M. A. (2013). Breaking the canon: indirect regulation of Wnt signaling in mammary stem cells by MMP3. Cell Stem Cell 13, 259-260.
Refers to Kessenbrock et al., 2013.
Chen, Y., Blair, K. and Smith, A. (2013). Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports 1, 209-217.
Ficz, G., Hore, T. A., Santos, F., Lee, H. J., Dean, W., Arand, J., Krueger, F., Oxley, D., Paul, Y. L., Walter, J., Cook, S. J., Andrews, S., Branco, M. R. and Reik, W. (2013). FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell 13, 351-359.
Folgueras, A. R., Guo, X., Pasolli, A., Stokes, N., Polak, L., Zheng, D. and Fuchs, E. (2013). Architectural Niche Organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell 13, 314-327.
Fong, H., Wang, C., Knoferle, J., Walker, D., Balestra, M. E., Tong, L. M., Leung, L., Ring, K. L., Seeley, W. W., Karydas, A., Kshirsager, M. A., Boxer, A. L., Kosik, K. S., Miller, B. L. and Huang, Y. (2013). Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports 1, 226-234.
Gazit, R., Garrison, B. S., Rao, T. N., Shay, T., Costello, J., Ericson, J., Kim, F., Collins, J. J., Regev, A., Wagers, A. J., Rossi, D. J. and The Immunological Genome Project Consortium. (2013). Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells. Stem Cell Reports 1, 266-280.
Kessenbrock, K., Dijkgraaf, G. J. P., Lawson, D. A., Littlepage, L. E., Shahi, P., Pieper, U. and Werb, Z. (2013). A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell 13, 300-313.
Lancaster, M. A., Renner, M., Martin, C. A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P. and Knoblich, J. A. (2013). Cerebral organoids model human brain development and microcephaly. Nature doi: 10.1038/nature12517.
Schepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C. and Passegué, E. (2013). Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 13, 285-299.
Tucker, B. A., Mullins, R. F., Streb, L. M., Anfinson, K., Eyestone, M. E., Kaalberg, E., Riker, M. J., Drack, A. V., Braun, T. A. and Stone, E. M. (2013). Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. eLife 2013;2:e00824.
Weidang, C. E., Russell, R., Tata, P. R., et al. (2013). TBX3 directs cell-fate decision toward mesendoderm. Stem Cell Reports 1, 248-265.
Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., Sena, B., Nahrendorf, M., Briscoe, D. M., Li, R. A., Wagers, A. J., Rossie, D. J., Pu, W. T., and Chien, K. R. (2013). Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol doi: 10.1038/nbt.2682.
Zhang, Z., Xiang, D., Heriyanto, F., Gao, Y., Qian, Z. and Wu, W. S. (2013). Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-baed repressor and TALEN. Stem Cell Reports 1, 218-225.