|This issue is sponsored by:|
|1. Editor's Message
Carl Wonders, PhD
ISSCR 11th Annual Meeting, Boston, Massachusetts, USA, June 12-15, 2013. A record number of more than 4,100 attendees from 56 countries joined the ISSCR in Boston for an excellent meeting this year. Read the highlights and view the award winners in Section 2 and on the ISSCR website.
Select presentations from ISSCR 2013 are now available on ISSCR Connect. Registrants of the ISSCR 11th Annual Meeting can now access select Concurrent talks on-demand on ISSCR Connect. Select Plenary sessions will be available to meeting registrants and all ISSCR Members on July 10, 2013. Read more in Section 3.
ISSCR Regional Forum Series 2013. Whether you were unable to join us in Boston or are looking for even more excellent stem cell science, the ISSCR invites you to attend two Regional Forums as part of the ISSCR Regional Forum Series 2013. Registration and Abstract Submission are now open for both Forums. Click the links below for more information on each forum.
Stem Cell Reports. The inaugural issue of the ISSCR’s new, online open-access journal Stem Cell Reports was published concurrently with the ISSCR 11th Annual Meeting. The next online release of papers will be July 11. View the latest online content on the .
ISSCR 2014: Save the date: ISSCR 12th Annual Meeting, Vancouver, British Columbia, Canada, June 18-21, 2014. Co-sponsored by Stem Cell Technologies.
Reach 14,000 - Sponsor The Pulse e-Newsletter. Did you know each month an exclusive sponsorship with ad space is available for the ISSCR's e-newsletter, The Pulse? This month’s sponsor, The Company of Biologists Ltd, benefits from exposure to more than 14,000 stem cell researchers, clinicians, regulatory officials, industry representatives, government authorities and others with an interest in stem cell research. Contact Amy Claver to reserve your space at the top of The Pulse.
|2. ISSCR 11th Annual Meeting Recap
ISSCR 11th Annual Meeting
June 12-15, 2013
Boston, Massachusetts, USA
Co-sponsored by the Harvard Stem Cell Institute
In June, the ISSCR returned to Boston, Massachusetts for the first time since 2004, as a record-breaking number of more than 4,100 attendees joined us for the ISSCR 11th Annual Meeting, co-sponsored by the Harvard Stem Cell Institute.
We would like to thank the 2013 Annual Meeting Program Committee, chaired by George Q. Daley, for developing a scientific program that reflected the strength and diversity of the stem cell field. Covering a wide range of topics and featuring an international lineup of speakers, many of whom were first-time presenters, this year’s meeting featured seven plenary sessions, 20 concurrent tracks spread over four sessions and other networking and educational sessions. New to this year’s meeting were the three-minute “Poster Briefs,” which allowed high-scoring poster abstract presenters the opportunity to give a three-slide oral talk during a relevant concurrent session in addition to their poster that evening. This addition to the program brought the total number of speakers to 198, and more than 1,800 posters were presented over three evening poster receptions, both records for an ISSCR Annual Meeting. The ISSCR thanks everyone who presented, and we extend our congratulations to the winners of the 2013 Junior Investigator Poster Awards (listed below).
During the evening of Tuesday, June 11, the Harvard Stem Cell Institute (HSCI) presented a Public Symposium in association with the ISSCR that featured nine Harvard-affiliated scientists presenting their work. The presentation were followed by a panel discussion with excellent and thought-provoking questions from the audience. The ISSCR would like to especially thank Brock Reeve and Maureen Herrmann at the HSCI for putting together an excellent event.
Prior to the start of the annual meeting, Wednesday morning attendees took part in the Industry Wednesday Symposia (IWS) and Focus Sessions that offered in-depth looks at a variety of topics in stem cell science. A total of two IWS sessions and two Focus Sessions were held and immediately preceded the start of the main program Wednesday afternoon. The ISSCR thanks Thermo Fisher Scientific and PerkinElmer for participating in the IWS sessions and the ISSCR Ethics and Public Policy Committee, Stem Cell COREdinates and the Allen Institute of Brain Science for organizing the Focus Sessions.
The ISSCR 11th Annual Meeting opened with the Presidential Symposium and opening remarks, first by David Scadden who reflected on the growth of the ISSCR and stem cell research since the last Boston meeting in 2004, and followed by ISSCR President Shinya Yamanaka who took a look back at his career in science, including his history presenting at ISSCR meetings dating back to a poster presented at the Boston meeting in 2004. Immediately following these remarks, the third annual McEwen Award for Innovation was presented to James A. Thomson, who was recognized for his work that reproducibly isolated pluripotent cell lines from human blastocysts, which was the first step in the study of human embryonic stem cells. Following the presentation of this award, Dr. Thomson gave the first talk of the session, which also included presentations by Douglas A. Melton, Edith Heard and Richard A. Young. The session closed with the sixth annual Anne McLaren Memorial Lecture, which was given by Elaine Fuchs who provided an excellent overview of her lab’s work using the skin as a model system for understanding stem cell behavior, tissue regeneration and cancer.
In addition to the McEwen Award for Innovation, two other awards were presented throughout the meeting. The third annual ISSCR Public Service Award was presented to Hiromitsu and Betty Ogawa in recognition of their extraordinary support of stem cell research in Japan and the USA, including support for Shinya Yamanaka, the Gladstone Institute in San Francisco, California, and their work with the ISSCR Global Advisory Council. Later in the meeting, Marius Wernig was presented with the University of Pittsburgh-ISSCR Outstanding Young Investigator Award for his work showing that previously specified cells can be reprogrammed directly to other distantly related cell types.
Continuing a tradition that started in 2011, the ISSCR invited a patient advocate to address the meeting attendees. This year, Andrés Treviño shared his family’s moving story of how his son, Andy, was born with a life-threatening disease of the immune system and whose life was saved by an umbilical cord blood transplant from his younger sister, Sofia. Watch his talk now on ISSCR Connect (available to the public).
This year’s meeting marked several firsts and new records for the ISSCR. On Friday morning, a plenary session that was jointly organized by the American Society of Gene and Cell Therapy and European Society of Gene and Cell Therapy was the first such session at an ISSCR Annual Meeting to be dedicated entirely to translational research. The new Poster Brief format allowed more high-scoring poster presenters the chance to speak during concurrent sessions, and a record number of abstract submissions meant a greater number of presentations (both oral and poster) than in previous ISSCR Annual Meetings. Finally, the ISSCR’s new online, open-access journal Stem Cell Reports had its debut issue concurrent with the annual meeting, and all meeting attendees received a free hardcopy of the issue.
The final plenary session of the meeting opened with an address from President-Elect Janet Rossant, who described her vision for the upcoming year, including a bold new communications strategy and the development of a translational and clinical research course. This year’s meeting concluded closing keynote was delivered by Eric Lander, who gave a fascinating talk about the secrets of the human genome that have been uncovered through the process of its sequencing and afterwards, including his recent work with non-coding RNAs.
This recap only touches on some of the events at this year’s meeting in Boston. An in-depth look at the science presented at the meeting will appear in the ISSCR pages of Stem Cell Reports this fall.
We congratulate the ISSCR Poster Award winners who were selected from 1,046 eligible abstracts on display in Boston: Yossi Buganim (Massachusetts Institute of Technology), Walid Khaled (Wellcome Trust Sanger Institute), Michelle Lin (Harvard), Benoit Sorre (The Rockefeller University), Christine Theodoris (University of California, San Francisco) and Meng Zhao (Stowers Institute for Medical Research).
The ISSCR also congratulates the recipients of the 2013 Travel Grants for travel to the 11th Annual Meeting, supported by the ISSCR and BD Biosciences. View the winners here.
|3. ISSCR Connect
The ISSCR's online educational platform is now hosting content from the ISSCR 11th Annual Meeting. Annual Meeting registrants have access to select Concurrent Sessions. NEW for 2013: Select Plenary lectures are available to all members of the ISSCR in addition to all meeting registrants.
Registrants of the ISSCR 11th Annual Meeting: Catch up on Concurrent Sessions you may have missed. Select Concurrent talks are being offered on-demand on ISSCR Connect. See below for the release schedule or click here to see an updated list of available talks.
Concurrent I - LAST CHANCE! Concurrent I sessions will only be available through tomorrow, July 10.
Concurrent II - Now Available through July 16
Concurrent III - AVAILABLE TODAY through July 23
Concurrent IV - Available July 16-30
NEW The following Plenary Sessions will available from July 10 - 24 to all ISSCR Members in addition to Annual Meeting registrants:
- Lawrence S.B. Goldstein, "Using Induced Pluripotent Stem Cells to Understand Alzheimer's Disease"
- Haruhisa Inoue, "Unraveling Neurodegenerative-disease Mechanisms Using Patient-specific Induced Pluripotent Stem Cells"
- David Williams, "Integrating Viral Vectors, Gene Transfer into Hematopoietic Stem Cells and Therapies in Human Monogenic Diseases"
- Joseph C. Wu, "Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling"
- George Q. Daley, "Milestones and Barriers in Hematopoietic Stem Cell Derivation from Pluripotent Stem Cells"
Ernest McCulloch Memorial Lecture
The following presentation is available via the Public Channel to anyone (simply register an account for access if you do not already have one):
Andres Trevino, "Andy and Sofia"
Patient Advocate Address
|4. Florence 2013 Regional Forum
Stem Cells in Translation
September 15 – 18, 2013
|Hotel Rate Guarantee Ends:
||July 15, 2013
|Abstract Submission Deadline
||July 17, 2013
The ISSCR invites you to Florence, Italy for Stem Cells in Translation, September 15-18, 2013, a Regional Forum that reflects the major role of European research centers in the exciting transition of stem cell research to clinical relevance.
Registration for this Forum includes admission to all educational sessions, exhibits, poster sessions and social events, as well as meeting materials including the final program and proceedings. Register online and save as much as $250 off of the on-site rate. ISSCR members enjoy additional savings; if you’re not yet a member, join today and receive the member rate immediately.
Reserve your hotel room today! The special negotiated rates for conference hotels are available only through July 15, so be sure to book your room before the rates expire.
Make your work a key part of the discussion: the Abstract Submission Deadline for poster presentations is July 17, 2013. Read the Call for Abstracts or submit an abstract today.
View the Preliminary Program.
What should you expect from this Regional Forum?
The overarching goal of the conference is to foster collaboration and facilitate discussion among the field’s leading researchers about what is needed to translate stem cell research into cell and gene therapies within a relaxed and comfortable environment. This focused meeting is expected to draw more than 500 attendees and hundreds of posters in addition to exhibitors with innovative technologies that will enable translational research. Learn more about the meeting, the science and the location on the Florence 2013 website.
|5. Suzhou 2013 Regional Forum
Stem Cells in Science and Medicine
October 14 – 17, 2013
The ISSCR is pleased to return to Suzhou and once again partner with Cold Spring Harbor Asia to present Stem Cells in Science and Medicine. The diverse program offers a wide range of stem cell topics including Stem Cells & Development, iPS and Reprogramming, Cancer Stem Cells and Therapy and more. View the complete list of sessions and confirmed speakers.
Registration and abstract submission for this meeting is now open through the Cold Spring Harbor Asia website. Please note that you must register for the meeting first if you wish to submit an abstract – you will be given a link and instructions for abstract submission in your registration confirmation email. The Early Registration and Abstract Submission Deadline is August 2, 2013.
More details, including hotel and travel information, can be found on the Stem Cells in Science and Medicine website.
|6. News Roundup
California, USA. On July 3, 2013, the California State senate joined the State Assembly in approving a bill that allows for the payment of compensation beyond “direct expenses” to women who donate oocytes for scientific research. Read more.
Japan. A Japanese government panel announced on June 27, 2013, that it was approving the world’s first clinical trial using human iPSCs. This trial will test the use of iPSC-derived retinal pigment epithelium in the treatment of age-related macular degeneration. Read more.
Washington, DC, USA. On June 13, 2013, the United States Supreme Court unanimously ruled that human genes are not patentable. Among other effects, this decision may help reduce the costs involved in certain types of genetic testing. Read more.
|7. Job Opportunities
Seeking a job? Have a job opening? Visit the ISSCR Job Bank. ISSCR members receive a discount on job postings.
Featured Job: Tenure-track Faculty Position, University of Texas Medical School at Houston. Four tenure-track positions are available for researchers with interests in pluripotent and adult stem cell research and/or regenerative medicine. Appointments will be made at the Assistant or Associate Professor levels based on experience and funding. Read the full posting here.
|9. Meetings and Courses
View the ISSCR's online events calendar for a complete listing of upcoming meetings and courses.
Stem Cells in Translation
ISSCR Regional Forum Series 2013
Sept. 15 - 18, 2013
Palazzo dei Congressi
Stem Cells in Science and Medicine
ISSCR Regional Forum Series 2013
Co-produced by ISSCR and Cold Spring Harbor Asia
Oct. 14-18, 2013
Stem Cell Meetings
MSC2013: Adult Stem Cell Therapy and Regenerative Medicine
August 19 - 21, 2013
Cleveland, OH USA
ISEH - 42nd Annual Scientific Meeting
Aug. 22 - 25, 2013
Abstract submission deadline: April 12, 2013
Discounted registration deadline: June 3, 2013
NHLBI Symposium on Cardiovascular Regenerative Medicine
September 25-26, 2013
National Institutes of Health
Bethesda, Maryland, USA
2013 Shanghai International Symposium on Cancer Stem Cells
Oct. 17 - 19, 2013
Tongji University, Shanghai, China
Abstract Submission Deadline: August 1, 2013
World Conference on Regenerative Medicine 2013
Oct. 23 - 25, 2013
TERMIS-AM 2013 Conference & Expo
November 10 - 13, 2013
Hyatt Regency Atlanta
Atlanta, Georgia, USA
Discounted Registration Deadline: September 15, 2013
Stem Cell Society Singapore Symposium 2013
November 18-19, 2013
Early Registration Deadline: August 31, 2013
Oral Presentation Submission Deadline: September 1, 2013
Poster Abstract Deadline: October 1, 2013
Online Registration Closes: November 4, 2013
2013 World Stem Cell Summit
December 4 - 6, 2013
San Diego, CA USA
Abstract Submission Deadline: October 29, 2013
Discounted Registration Deadline: October 29, 2013
Hotel Discount Deadline: November 8, 2013
2013 American Society for Cell Biology Annual Meeting
December 14 - 18, 2013
New Orleans, LA USA
Stem Cell Courses
The 21st School in Life Sciences: Stem Cells and Regenerative Biology
July 21-25, 2013
The Hebrew University of Jerusalem
Application Deadline: May 31, 2013
EMBO Practical Course: Current Methods in Cell Biology
Sept. 26 - Oct. 4, 2013
Regularly Occurring Courses
Cellular Dynamics International (CDI): iCertification Courses
Madison, WI, USA
Two-day training courses for CDI's iCell Products.
Life Technologies: LifeLab Pluripotent Stem Cell Workshops
Various Locations, Global
Training in culturing and characterizing hESCs and iPSCs and reprogramming techniques offered at various locations throughout the year.
STEMCELL Technologies: Training Courses
Vancouver, BC, Canada
Ongoing series of a range of specialized stem cell courses.
|10. Literature Highlights
Stem Cell Reports
The next round of online articles will be published in the ISSCR’s new open-access journal, Stem Cell Reports, on July 11. To find out more about the journal, including instructions for authors, visit the Stem Cell Reports website.
The June 15, 2013, issue of Development was devoted to Stem Cells and Regeneration. See the complete Table of Contents.
Baumann, K. (2013). Tailored splicing patterns. Nat Rev Mol Cell Biol doi:10.1038/nrm3621.
Refers to Han et al., 2013.
Burgess, D. J. (2013). Maintaining genomic integrity. Nat Rev Genet doi:10.1038/nrg3536.
Refers to Meng et al., 2013.
Dalerba, P. and Clarke, M. F. (2013). Oncogenic miRNAs and the perils of losing control of a stem cell’s epigenetic identity. Cell Stem Cell 13, 5-6.
Refers to Song et al., 2013a and Song et al., 2013b.
Smith, A. (2013). Nanog heterogeneity: tilting at windmills? Cell Stem Cell 13, 6-7
Refers to Faddah et al., 2013 and Filipczyk et al., 2013.
Tantin, D. (2013). Oct transcription factors in development and stem cells: insights and mechanisms. Development 140, 2857-2866.
Sandoe, J. and Eggan, K. (2013). Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci 16, 780-789.
Faddah, D. A., Wang, H., Cheng, A. W., Katz, Y., Buganim, Y. and Jaenisch, R. (2013). Single-cell analysis reveals that expression of Nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell 13, 23-29.
Filipczyk, A., Gkatzis, K., Fu, J., Hoppe, P. S., Lickert, H., Anastassiadis, K. and Schroeder, T. (2013). Biallelic expression of Nanog protein in mouse embryonic stem cells. Cell Stem Cell 13, 12-13.
Frum, T., Halbisen, M. A., Wang, C., Amiri, H., Robson, P. and Ralston, A. (2013). Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell 25, 610-622.
Han, H., Irimia, M., Ross, P. J., Sung, H. K., Alipanahi, B., David, L., Golipour, A., Gabut, M., Michael, I. P., Nachman, E. N., Wang, E., Trcka, D., Thompson, T., O’Hanlon, D., Slobodeniuc, V., Barbosa-Morais, N. L., Burge, C. B., Moffat, J., Frey, B. J., Nagy, A., Ellis, J., Wrana, J. L. and Blencowe, B. J. (2013). MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature 498, 241-245.
Meng, L., Lin, T., Peng, G., Hsu, J. K., Lee, S., Lin, S. Y. and Tsai, R. Y. L. (2013). Nucleostemin deletion reveals an essential mechanism that maintains the genetic stability of stem and progenitor cells. Proc Natl Acad Sci USA 110, 11415-11420.
Song, S. J., Ito, K., Ala, U., Kats, L., Webster, K., Sun, S. M., Jongen-Lavrencic, M., Manova-Todorova, K., Teruya-Feldstein, J., Avigan, D. E., Delwel, R. and Pandolfi, P. P. (2013a). The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell 13, 87-101.
Song, S. J., Poliseno, L., Song, M. S., Ala, U., Webster, K., Ng, C., Beringer, G., Brikbak, N. J., Yuan, X., Cantley, L. C., Richardson, A. L. and Pandolfi, P. P. (2013b). MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell doi:10.1016/j.cell.2013.06.026.
Takebe, T., Sekine, K., Enomura, M., Koike, H., Kumura, M., Ogaeri, T., Zhang, R. R., Ueno, Y., Zheng, Y. W., Koike, N., Aoyama, S., Adachi, Y. and Taniguchi, H. (2013). Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature doi:10.1038/nature12271.
Tan, Y., Xue, Y., Song, C. and Grunstein, M. (2013). Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency. Proc Natl Acad Sci USA 110, 11493-11498.